2024

Mixed selectivity: Cellular computations for complexity.
Tye KM, Miller EK, Taschbach FH, Benna MK, Rigotti M, Fusi S.
Neuron: 2024 May 9 doi: 10.1016/j.neuron.2024.04.017
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Reward contingency gates selective cholinergic suppression of amygdala neurons.
Kimchi EY, Burgos-Robles A, Matthews GA, Chakoma T, Patarino M, Weddington J, Siciliano CA, Yang W, Foutch S, Simons R, Fong M, Jing M, Li Y, Polley DB, Tye KM.
eLife: 2024 Feb 20 doi: 10.7554/eLife.89093.1
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bioRxiv: 2022 Feb 05 doi: 10.1101/2022.02.04.479188.
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Supporting electrophysiological data for: Reward contingency gates selective cholinergic suppression of amygdala neurons [Dataset].
Keyes, LR; Tye, KM; Kimchi, EY.
Dryad. 2024 doi: 10.5061/dryad.dbrv15f85  Access Data »

2023

Reward contingency gates selective cholinergic suppression of amygdala neurons.
Kimchi EY, Burgos-Robles A, Matthews GA, Chakoma T, Patarino M, Weddington J, Siciliano CA, Yang W, Foutch S, Simons R, Fong M, Jing M, Li Y, Polley DB, Tye KM.
eLife: 2023 Jul 4 doi: 10.7554/eLife.89093.1
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bioRxiv: 2022 Feb 05 doi: 10.1101/2022.02.04.479188.
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Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking. 
Patel RR, Patarino M, Kim K, Pamintuan R, Taschbach FH,Li H, Lee CR, van Hoek A, Castro R, Cazares C, Miranda RL, Jia C, Delahanty J, Batra K, Keyes LR, Libster A, Wichmann R, Pereira TD, Benna MK, Tye KM.
bioRxiv: 2023 Nov 10 doi: https://doi.org/10.1101/2023.11.09.566421
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AlphaTracker: A Multi-Animal Tracking and Behavioral Analysis Tool. 
Zhang R, Fang HS, Chen Z, Zhang YE, Bal A, Zhou H, Rock RR, Padilla-Coreano N, Keyes LR, Zhu H, Li YL, Komiyama T, Tye KM, Lu C.
Frontiers in Beh Neuro. 2023 May 10. doi: 10.3389/fnbeh.2023.1111908
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bioRxiv: 2020 Dec 6. 10.1101/2020.12.04.405159.
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Anxiety and depression: A top-down bottom-up model of circuit function.
LeDuke DO*, Borio M*, Miranda R, & Tye KM.
Ann N Y Acad Sci (Early View): 2023 May 2 doi:  https://doi.org/10.1111/nyas.14997. Online ahead of print.
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Thalamus sends information about arousal but not valence to the amygdala.
Leppla CA*, Keyes LR*, Glober G, Matthews GA, Batra K, Jay M, Feng Y, Chen HS, Mills F, Delahanty J, Olson JM, Nieh EH, Namburi P, Wildes C, Wichmann R, Beyeler A, Kimchi EY,  Tye KM.
Psychopharmacology: 2023 Mar doi: https://doi.org/10.1007/s00213-022-06284-5. Epub 22 Dec 16
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2022

Amygdalostriatal transition zone neurons encode sustained valence to direct conditioned behaviors.
Mills F, Lee C, Howe JR, Li H, Shao S, Keisler MN, Lemieux ME, Taschbach FH, Keyes LR, Borio M, Chen HS, Patel RR, Gross AL, Delahanty J, Cazares C, Maree L, Wichmann R, Pereira TD, Benna MK, Root CM, & Tye KM.
Cell Sneak Peek: 2022 Oct 29 Under Review Read Abstract»
biorXiv: 2022 Oct 29 doi:  https://doi.org/10.1101/2022.10.28.514263.
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Neurotensin orchestrates valence assignment in the amygdala.
Li H, Namburi P,  Olson JM, Borio M, Lemieux ME, Beyeler A, Calhoon GG, Hitora-Imamura N, Coley AA, Libster A, Bal A, Jin X, Wang H, Jia C, Choudhury SR, Shi X, Felix-Ortiz AC, de la Fuente V, Barth VP, King HO, Izadmehr EM, Revanna JS, Batra K, Fischer KB, Keyes LR, Padilla-Coreano N, Siciliano CA, McCullough KM, Wichmann R, Ressler KJ, Fiete IR, Zhang F, Li Y & Tye KM.
Nature: 2022 July 20 doi: https://doi.org/10.1038/s41586-022-04964-y.
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Dynamic influences on the neural encoding of social valence
Padilla-Coreano N, Tye KM, Zelikowsky M
Nat Rev Neurosci: 2022 Jul 12 doi: 10.1038/s41583-022-00609-1
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Cortical ensembles orchestrate social competition through hypothalamic outputs.
Padilla-Coreano N, Batra K, Patarino M, Chen Zexin, Rock, RR, Zhang R, Hausmann SB, Weddington JC, Patel R, Zhang YE, Fang H, Mishra S, LeDuke DO, Revanna J, Li H, Borio M, Pamintuan R, Bal A, Keyes LR, Libster A, Wichmann R, Mills F, Taschbach FH, Matthews GA, Curley JP, Fiete IR, Lu C,   Tye KM.
Nature: 603, 667-671, 2022 Mar 16 https://doi.org/10.1038/s41586-022-04507-5.
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Reward contingency gates selective cholinergic suppression of amygdala neurons.
Kimchi EY, Burgos-Robles A, Matthews GA, Chakoma T, Patarino M, Weddington J, Siciliano CA, Yang W, Foutch S, Simons R, Fong M, Jing M, Li Y, Polley DB, Tye KM.
bioRxiv: 2022 Feb 05 doi: 10.1101/2022.02.04.479188.
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Neural systems that facilitate the representation of social rank.
Dwortz MF, Curley JP, Tye KM, Padilla-Coreano N
Phil. Trans. R Soc. B: 2022 Jan 10 doi: 10.1098/rstb.2020.0444.
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2021

Separable Dorsal Raphe Dopamine Projections Mediate Sociability and Valence.
Matthews GA, Lemieux ME, Brewer EM, Borio M, Miranda R, Keyes LR, Peroni E, Pereira GS, Moraga AL, Palle A, Lee CR, Kimchi EY, Padilla-Coreano N, Wichmann R, Tye KM.
Research Square. 2021 Dec 3. doi: 10.21203/rs.3.rs-1025403/v1.
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Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity hypertubes.
Tsuda B, Pate SC, Tye KM, Siegelmann HT, Sejnowski TJ.
bioRxiv: 2021 May 31 doi: 10.1101/2021.05.31.446462.
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Valence processing in the PFC: Reconciling circuit-level and systems-level views.
Coley A, Padilla-Coreano N, Patel R, Tye KM.
Book Chapter in International Review of Neurobiology: Volume 158, 2021.
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The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation.
Lee CR, Chen A, Tye KM.
Cell. 2021 Mar 18. doi: 10.1016/j.cell.2021.02.028.
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2020

Acute social isolation evokes midbrain craving responses similar to hunger.
Tomova L, Wang KL, Thompson T, Matthews GA, Takahashi A, Tye KM, Saxe R.
Nat Neurosci. 2020 Dec. doi: 10.1038/s41593-020-00742-z.
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A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex.
Tsuda B, Tye KM, Siegelmann HT, Sejnowski TJ.
Proc Natl Acad Sci U.S.A. 2020 Nov. 24. doi: 10.1073/pnas.2009591117.
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A cortical-hypothalamic circuit decodes social rank and promotes dominance behavior.
Padilla-Coreano N, Batra K, Patarino M, Chen Z, Rock R, Zhang R, Hausmann S, Weddington J, Patel R, Zhang Y, Fang HS, Keyes L, Liebster A, Matthews G, Curley J, Fiete I, Lu C, Tye KM.
Nature Portfolio. 2020 Nov 4. doi: 110.21203/rs.3.rs-94115/v1.
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Context-dependent plasticity of adult-born neurons regulated by cortical feedback
Wu A, Yu B, Chen Q, Matthews GA, Lu C, Campbell E, Tye KM, Komiyama T.
Sci Adv. 2020 Oct 16. doi: 10.1126/sciadv.abc8319.
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Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator
Shemesh O, Linghu C, Piatkevich K, Goodwin D, Celiker O, Gritton H, Romano M, Gao R, Yu C, Tseng H, Bensussen S, Narayan S, Yang C, Freifeld L, Siciliano C, Gupta I, Wang J, Pak N, Yoon Y, Ullmann J, Guner-Ataman B, Noamany H, Steintopf Z, Park W, Asano S, Keating A, Trimmer J, Reimer J, Tolias A, Bear M, Tye K, Han X, Ahrens M, Boyden E
Neuron. 2020 Jun 26. doi: 10.1016/j.neuron.2020.05.029.
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2019

A cortical-brainstem circuit predicts and governs compulsive alcohol drinking.
Siciliano CA, Noamany H, Chang CJ, Brown AR, Chen X, Leible D, Lee JJ, Wang J, Vernon AN, Vander Weele CM, Kimchi EY, Heiman M & Tye KM.
Science. 2019 Nov 22. doi: 10.1126/science.aay1186
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The neuroscience of unmet social needs.
Tomova L, Tye KM, Saxe R.
Soc Neurosci. 2019 Nov 20:1-11. doi: 10.1080/17470919.2019.1694580.
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Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior.
Padilla-Coreano N, Canetta S, Mikofsky RM, Alway E, Passecker J, Myroshnychenko MV, Garcia-Garcia AL, Warren R, Teboul E, Blackman DR, Morton MP, Hupalo S, Tye KM, Kellendonk C, Kupferschmidt DA, Gordon JA.
Neuron. 2019 Nov 6;104(3):601-610.e4. doi: 10.1016/j.neuron.2019.08.006.
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Viewpoints: Approaches to defining and investigating fear.
Mobbs D, Adolphs R, Fanselow MS, Barrett LF, LeDoux JE, Ressler K, Tye KM.
Nat Neurosci. 2019 Aug;22(8):1205-1216. doi: 10.1038/s41593-019-0456-6.
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Neural mechanisms of social homeostasis.
Matthews GA & Tye KM.
Ann N Y Acad Sci. 2019 Mar 15. doi: 10.1111/nyas.14016.
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Dopamine tunes prefrontal outputs to orchestrate aversive processing.
Vander Weele CM, Siciliano CA & Tye KM.
Brain Research. 2019 Jun 15;1713:16-31. doi: 10.1016/j.brainres.2018.11.044.
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Leveraging calcium imaging to illuminate circuit dysfunction in addiction.
Siciliano CA & Tye KM.
Alcohol. 2019 Feb;74:47-63. doi: 10.1016/j.alcohol.2018.05.013.
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2018

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli.
Vander Weele C, Siciliano C, Matthews G, Namburi P, Izadmehr E, Espinel I, Nieh E, Schut E, Padilla-Coreano N, Burgos-Robles A, Chang CJ, Kimchi E, Beyeler A, Wichmann R, Wildes C & Tye K.
Nature. 2018 Nov 7. doi:10.1038/s41586-018-0682-1.
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Neural Circuit Motifs in Valence Processing.
Tye K.
Neuron. 2018 Oct. 24. doi:10.1016/j.neuron.2018.10.001.
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Clustering Time Series with Nonlinear Dynamics: A Bayesian Non-Parametric and Particle-Based Approach.
Lin A, Zhang Y, Heng J, Allsop S, Tye K, Jacob P & Ba D.
arXiv. 2018 Oct 23. arXiv:1810.09920v2.
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Double threat in striatal dopamine signaling.
Siciliano C, Mills F & Tye K.
Nature neuroscience. 2018 Sept 26. doi:10.1038/s41593-018-0243-9.
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Sequential Detection of Regime Changes in Neural Data.
Banerjee T, Allsop S, Tye K, Ba D & Tarokh V.
arXiv. 2018 Sept 2. arXiv:1809.00358.
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Corticoamygdala transfer of socially derived information gates observational learning.
Allsop S, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, C. Felix-Ortiz A, Vienne A, Beyeler A, Izadmehr E, Glober G, Cum M, Stergiadou J, Anandalingam K, Farris K, Namburi P, Leppla C, Weddington J, Nieh E, Smith A, Ba D, Brown E & Tye K.
Cell. 2018 May 3,. doi:10.1016/j.cell.2018.04.004.
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Acute Food Deprivation Rapidly Modifies Valence-Coding Microcircuits in the Amygdala.
Gwendolyn G Calhoon, Amy K Sutton, Chia-Jung Chang, Avraham M Libster, Gordon F Glober, Clémentine L Lévêque, G David Murphy, Praneeth Namburi, Christopher A Leppla, Cody A Siciliano, Craig P Wildes, Eyal Y Kimchi, Anna Beyeler & Kay M Tye
BioRxiv. 2018 Mar. 19,. doi:10.1101/285189.
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Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting or projection neurons.
Chatterjee S, Sullivan H, MacLennan B, Xu R, Hou Y, Lavin T, Lea N, Michalski J, Babcock K, Dietrich S, Matthews G, Beyeler A, Calhoon G, Glober G, Whitesell J, Yao S, Cetin A, Harris J, Zeng H, Tye K, Reid RC & Wickersham I.
Nature Neuroscience. 2018 March 5, doi:10.1038/s41593-018-0091-7.
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Editorial Overview: Neurobiology of Behavior.
Tye K & Uchida N.
Current Opinion in Neurobiology. 2018 March, 49, doi:10.1016/j.conb.2018.02.019.
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Organization of valence-encoding and projection-defined neurons in the basolateral amygdala.
Beyeler A, Chang CJ, Silvestre M, Lévêque C, Namburi P,  Wildes C & Tye K.
Cell Reports. 2018 Jan, 22:905-922, doi:10.1016/j.celrep.2017.12.097.
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2017

Acute stress induces long-lasting alterations in the dopaminergic system in female mice.
Wichmann R, Vander Weele C, Yosafat A, Schut E, Verharen J, Sridharma S, Siciliano C, Izadmehr E, Farris K, Wildes C, Kimchi E  & Tye K.
BioRxiv. 2017 July, preprint, doi: https://doi.org/10.1101/168492.
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A light- and calcium-gated transcription factor for imaging and manipulating activated neurons.
Wang W,  Wildes C, Pattarabanjird T, Sanchez M, Glober G, Matthews G, Tye K & Ting A.
Nature Biotechnology. 2017 Sep, 35(9):864-871, doi: 10.1038/nbt.3909, Epub 2017 Jun 26.
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Endocannabinoid signaling in the control of social behavior.
Wei D, Allsop S, Tye K & Piomelli D.
Trends in Neurosciences. 2017 Jul, 40(7):385-396, doi: 10.1016/j.tins.2017.04.005, Epub 2017 May 26.
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Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.
Burgos-Robles A, Kimchi E, Izadmehr E, Porzenheim MJ, Ramos-Guasp W, Nieh E, Felix-Ortiz A, Namburi P, Leppla C, Presbrey K, Anandalingam K, Pagan-Rivera P, Anahtar M, Beyeler A and Tye K.
Nature Neuroscience. 2017 Jun, 20(6):824-835, doi: 10.1038/nn.4553, Epub 2017 Apr 24.
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2016

Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation.
Nieh E, Vander Weele C, Matthews G, Presbrey K, Wichmann R, Leppla C, Izadmehr E, Wildes C and Tye K.
Neuron.016 Jun 15, 90(6):1286-1298, doi: 10.1016/j.neuron.2016.04.035, Epub 2016 May 26.
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Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval.
Beyeler A, Namburi P, Glober G, Simonnet C, Calhoon G, Conyers G, Luck R,  Wildes C and Tye K.
Neuron. 2016 Apr 20, 90(2):348-361, doi: 10.1016/j.neuron.2016.03.004, Epub 2016 Mar 31.
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Dorsal raphe dopamine neurons represent the experience of social isolation.
Matthews G, Nieh E, Vander Weele C, Halbert S, Pradhan R, Yosafat A, Glober G, Izadmehr E, Thomas R, Lacy G, Wildes C, Ungless M and Tye K
Cell. 2016 Feb 11, 164(4):617-31, doi: 10.1016/j.cell.2015.12.040.
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Architectural representation of valence in the limbic system.
Namburi P, Al-Hasani R, Calhoon G, Bruchas M and Tye K
Neuropsychopharmachology. 2016 Jun, 41(7):1697-715, doi: 10.1038/npp.2015.358, Epub 2015 Dec 9.
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2015

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex.
Felix-Ortiz AF, Burgos-Robles A, Bhagat ND, Leppla CA and Tye KM.
Neuroscience. 2016 May 3, 321:197-209, doi: 10.1016/j.neuroscience.2015.07.041, Epub 2015 Jul 21.
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Resolving the neural circuits of anxiety.
Calhoon GG  & Tye KM.
Nature Neuroscience. 2015 Oct, 18(10):1394-404, doi: 10.1038/nn.4101, Epub 2015 Sep 25.
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A circuit mechanism for differentiating positive and negative associations.
Namburi P, Beyeler A, Yorozu S, Calhoon G, Halbert SA, Wichmann R, Holden S, Mertens K, Anahtar M, Felix-Ortiz A, Wickersham I, Gray J & Tye K.
Nature.  2015 Apr 30, 520(7549):675-8, doi: 10.1038/nature14366.
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Decoding neural circuits that control compulsive sucrose seeking.
Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, Neve R, Wildes CP, and Tye KM.
Cell. 2015 Jan 29, 160(3):528-41, doi: 10.1016/j.cell.2015.01.003.
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From circuits to behaviour in the amygdala.
Janak PH & Tye KM.
Nature. 2015 Jan 15, 517(7534):284-92, doi: 10.1038/nature14188.
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Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.
Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR,  Arey RN, Enwright III JF, Jacobsen JPR, Kumar S, Remillard EM, Caron MG, Deisseroth K and McClung CA.
Mol Psychiatry. 2015 Nov, 20(11):1406-19, doi: 10.1038/mp.2014.167, Epub 2015 Jan 6.
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2014

Neural circuit reprogramming: A new paradigm for treating neuropsychiatric disease?
Tye KM.
Neuron. 2014 Sep 17, 83(6):1259-61, doi: 10.1016/j.neuron.2014.08.022.
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Noninvasive optical inhibition with a red-shifted microbial rhodopsin.
Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES.
Nature Neuroscience. 2014 Aug 17, (8):1123-9. doi: 10.1038/nn.3752.
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Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.
Allsop SA, Vander Weele CM, Wichmann R, Tye KM.
Frontiers in Behavioral Neuroscience. 2014 Jul 16, 8:241, doi: 10.3389/fnbeh.2014.00241, eCollection 2014.
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Natural neural projection dynamics underlying social behavior.
Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K.
Cell. 2014 Jun 19, 157(7):1535-51, doi: 10.1016/j.cell.2014.05.017.
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Deciphering memory function with optogenetics.
Beyeler A, Eckhardt CA, Tye KM.
Progress in Molecular Biology and Translational Science. 2014, 122:341-90, doi: 10.1016/B978-0-12-420170-5.00012-X.
PubMed »

PTEN knockdown alters dendritic spine/protrusion morphology, not density.
Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM.
The Journal of Comparative Neurology. 2014 Apr 1, 522(5):1171-90, doi: 10.1002/cne.23488.
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Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior.
Felix-Ortiz AC, Tye KM.
The Journal of Neuroscience. 2014 Jan 8, 34(2):586-95, doi: 10.1523/JNEUROSCI.4257-13.2014.
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2013

BLA to vHPC inputs modulate anxiety-related behaviors.
Felix-Ortiz AC, Beyeler A, Seo C, Leppla CA, Wildes CP, Tye KM.
Neuron. 2013 Aug 21, 79(4):658-64, doi: 10.1016/j.neuron.2013.06.016.
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Progress in understanding mood disorders: optogenetic dissection of neural circuits.
Lammel S, Tye KM, Warden MR.
Genes, Brain, and Behavior. 2014 Jan, 13(1):38-51, doi: 10.1111/gbb.12049, Epub 2013 Jun 11.
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Diverging neural pathways assemble a behavioural state from separable features in anxiety.
Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K.
Nature. 2013 Apr 11, 496(7444):219-23, doi: 10.1038/nature12018, Epub 2013 Mar 20.   
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Dopamine neurons modulate neural encoding and expression of depression-related behaviour.
Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K.
Nature. 2013 Jan 24, 493(7433):537-541, doi: 10.1038/nature11740, Epub 2012 Dec 12.
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2012

Glutamate inputs to the nucleus accumbens: does source matter?
Tye KM.
Neuron. 2012 Nov 21, 76(4):671-3, doi: 10.1016/j.neuron.2012.11.008.
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A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, Adhikari A, Tye KM, Frank LM, Deisseroth K.
Nature. 2012 Dec 20, 492(7429):428-32, doi: 10.1038/nature11617.
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Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors.
Nieh EH, Kim SY, Namburi P, Tye KM.
Brain Research. 2013 May 20, 1511:73-92, doi: 10.1016/j.brainres.2012.11.001, Epub 2012 Nov 8..
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Input-specific control of reward and aversion in the ventral tegmental area.
Lammel S, Lim BK, Ran C, Huang KW, Betley MJ, Tye KM, Deisseroth K, Malenka RC.
Nature. 2012 Nov 8, 491(7423):212-7, doi: 10.1038/nature11527, Epub 2012 Oct 14.
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Optogenetic investigation of neural circuits underlying brain disease in animal models.
Tye KM, Deisseroth K.
Nature Reviews Neuroscience. 2012 Mar 20, 13(4):251-66, doi: 10.1038/nrn3171.
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GABA neurons of the VTA drive conditioned place aversion.
Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouebe G, Deisseroth K, Tye KM, Luscher C.
Neuron. 2012 Mar 22, 73(6):1173-83, doi: 10.1016/j.neuron.2012.02.015, Epub 2012 Mar 21.
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2011

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins.
Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O’Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O, Deisseroth K.
Nature Methods. 2011 Dec 18, 9(2):159-72, doi: 10.1038/nmeth.1808.
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Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.
Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K.
Neuron. 2011 Dec 8, 72(5):721-33, doi: 10.1016/j.neuron.2011.10.028.
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Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking.
Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A.
Nature. 2011 Jun 29, 475(7356):377-80, doi: 10.1038/nature10194.
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High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels.
Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG.
Proceedings of the National Academy of Sciences of the United States of America. 2011 May 3, 108(18):7595-600, doi: 10.1073/pnas.1017210108, Epub 2011 Apr 19.  
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Amygdala circuitry mediating reversible and bidirectional control of anxiety.
Tye KM, Prakash R, Kim SY, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C, Deisseroth K.
Nature. 2011 Mar 17, 471(7338):358-62, doi: 10.1038/nature09820, Epub 2011 Mar 9.
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2010

Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.
Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A.
Current Topics in Behavioral Neurosciences. 2010, 3:3-27, doi: 10.1007/7854_2009_23.
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Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.
Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye KM, Bonci A.
Neuron. 2010 Mar 11m 65(5):682-94, doi: 10.1016/j.neuron.2010.02.015.
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Methylphenidate facilitates learning-induced amygdala plasticity.
Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A.
Nature Neuroscience. 2010 Apr, 13(4):475-81, doi: 10.1038/nn.2506, Epub 2010 Mar 7. 
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Amygdala neural encoding of the absence of reward during extinction.
Tye KM, Cone JJ, Schairer WW, Janak PH.
The Journal of neuroscience. 2010 Jan 6, 30(1):116-25, doi: 10.1523/JNEUROSCI.4240-09.2010.
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2008

Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning.
Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH.
Nature. 2008 Jun 26, 453(7199):1253-7, doi: 10.1038/nature06963, Epub 2008 May 11.
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2007

Amygdala neurons differentially encode motivation and reinforcement.
Tye KM, Janak PH.
The Journal of Neuroscience. 2007 Apr 11, 27(15):3937-45. doi: 10.1523/JNEUROSCI.5281-06.2007.
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